Clinical outcome of cerebrospinal fluid shunts in patients with leptomeningeal carcinomatosis
نویسندگان
چکیده
منابع مشابه
Leptomeningeal carcinomatosis: prognostic implications of clinical and cerebrospinal fluid features.
BACKGROUND Leptomeningeal carcinomatosis (LC) represents a devastating complication of systemic cancer, and patients with LC have a dismal prognosis and increased mortality. The few studies that have focused on the evaluation of prognostic factors in patients with LC have resulted in contradictory results. Thus, the treatment of LC remains controversial, and no straightforward guidelines exist ...
متن کاملDiagnostic and prognostic values of cerebrospinal fluid CYFRA 21-1 in patients with leptomeningeal carcinomatosis
OBJECTIVES To investigate the diagnostic and prognostic values of cerebrospinal fluid (CSF) CYFRA 21-1 in patients with leptomeningeal carcinomatosis (LMC). METHODS Concentration of CSF CYFRA 21-1 was detected using electro-chemiluminescent immunoassay. The difference in level of CYFRA 21-1 between 61 patients with LMC and 200 patients with other neurological disease was evaluated, and diagno...
متن کاملCerebrospinal fluid metabolomic profiles can discriminate patients with leptomeningeal carcinomatosis from patients at high risk for leptomeningeal metastasis
Purpose Early diagnosis of leptomeningeal carcinomatosis (LMC) is necessary to improve outcomes of this formidable disease. However, cerebrospinal fluid (CSF) cytology is frequently false negative. We examined whether CSF metabolome profiles can be used to differentiate patients with LMC from patients having a risk for development of LMC. Results A total of 10,905 LMIs were evaluated using PC...
متن کاملMolecular characterization of cerebrospinal fluid tumor cells associated with leptomeningeal carcinomatosis
Leptomeningeal carcinomatosis (LC) is a devastating and lethal complication of systemic cancer involving the spread of tumor cells to the meninges and the cerebrospinal fluid (CSF). Efforts focused on molecular analysis of CSF tumor cells (or CSFTCs) are scarce; hence, the biology of these cells remains poorly understood. Our group recently reported a study on molecular characterization of CSFT...
متن کاملMolecular profiling of tumor cells in cerebrospinal fluid and matched primary tumors from metastatic breast cancer patients with leptomeningeal carcinomatosis.
Although leptomeningeal carcinomatosis is a well-established clinical syndrome, virtually nothing is known about the tumor cells responsible for this particularly aggressive metastatic process. To isolate cerebrospinal fluid-derived tumor cells (CSFTC) from 15 patients with metastatic breast cancer diagnosed with leptomeningeal carcinomatosis, CSF samples were subjected to a two-step method inv...
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ژورنال
عنوان ژورنال: World Journal of Surgical Oncology
سال: 2019
ISSN: 1477-7819
DOI: 10.1186/s12957-019-1595-7